Claire Littleton was one of the middle section survivors of Oceanic Flight 815. When she was seventeen, Claire was involved in a car crash which caused her mother to fall into a coma for five years. The accident in turn led her to meet her biological father for the first time since he left her and her mother when Claire was younger. Claire later became pregnant and, with some coaxing from a psychic, decided to fly to LA to give the baby up for adoption, putting her on the fated flight.
During her time on the Island, she entered into an inconsistent relationship with fellow survivor Charlie Pace. She was kidnapped by one of the Others, Ethan Rom, and taken to their camp where she was drugged and tested because of her pregnancy. After escaping, Claire suffered amnesia but found comfort in Charlie and her memory eventually returned. She later gave birth to her son, Aaron Littleton, and did her best to take care of him despite being a reluctant mother. Her relationship with Charlie grew stronger after he rescued Aaron from Danielle Rousseau, but when Claire learned of Charlie’s past with drugs and witnessed his erratic behavior, she became reluctant to let him into her and Aaron’s life. Later, when Aaron became sick, Claire, worried it was a side effect of what the Others did to her, traveled to the Staff to look for medicine. The station triggered memories of her capture. She eventually forgave Charlie after she learned of Desmond’s visions of Charlie’s death, and told him she wouldn’t give up on him. When Charlie sacrificed himself to save the other survivors, Claire heeded his warning about the people on the freighter not being who they said they were and joined Locke’s group during the split.
During Keamy’s attack on the Barracks, her house was destroyed, but strangely Claire was unharmed. When the Monster attacked the mercenaries, she went with Aaron, Sawyer and Miles into the jungle. On the way to the beach camp, she saw her dead father, followed him into the jungle and disappeared, leaving Aaron behind. She was then seen with “Christian” in Jacob’s cabin by Locke. She appeared eerily calm and did not inquire about Aaron. Three years later she reappeared, saving Jin, who was being attacked by the Others. According to Dogen she has been “infected” beyond redemption. She attempted to kill Kate, but was stopped by the Man in Black, who she has been residing with for the past 3 years. She left his side after Kate promised to get her home to Aaron, but was reunited with him after the debacle on Widmore’s Sub. She went against him again when she realized he intended to kill all her friends to leave the Island. Claire finally escaped the Island on the Ajira plane, along with Kate, Sawyer, Frank, Richard and Miles.
In the flash-sideways, she was reunited with her deceased lover, Charlie Pace after giving birth to Aaron, and along with their friends, they moved on.